Protamine dose to neutralize heparin at the completion of cardiopulmonary bypass can be reduced significantly without affecting post-operative bleeding

Background: Systemic anticoagulation with heparin during cardiopulmonary bypass (CPB) should be neutralized by protamine administration to restore normal hemostasis. Our previous study showed the protamine-to-heparin ratio (P-to-H) of 1:1 (1 mg protamine:100 IU circulating heparin; 1.0 Ratio) is lik...

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Detalles Bibliográficos

Principais autores:	Lee Min-Ho, Beck Matthew, Shann Kenneth
Formato:	Artigo
Idioma:	Inglês
Publicado:	EDP Sciences 2023-09-01
Series:	The Journal of ExtraCorporeal Technology
Assuntos:	protamine-to-heparin ratio protamine dose post-operative bleeding heparin protamine titration cardiopulmonary bypass
Acceso en liña:	https://ject.edpsciences.org/articles/ject/full_html/2023/03/ject230010/ject230010.html
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