FBXW7 mutations reprogram glucose metabolism by activating the ETV6-GLUT1 axis

Abstract The progression of endometrial cancer (EC) involves substantial metabolic reprogramming, frequently driven by mutations in tumor suppressors and oncogenes. In this study, we identify a previously unrecognized pathway through which FBXW7 mutations rewire glucose metabolism in EC cells. Speci...

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Hlavní autoři:	Siqi Fei, Xiayun Xu, Tingrui Wang, Xinyue Jiang, Hanrong Zhu, Yingji Chen, Renjie Yuan, Zeheng Lv, Zhijian Gao, Huanxin Liu, Xiaojun Chen, Chenji Wang, Kun Gao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-02-01
Edice:	Molecular Cancer
Témata:	FBXW7 Ubiquitination Glucose metabolism Endometrial cancer
On-line přístup:	https://doi.org/10.1186/s12943-026-02605-w
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