Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma

Abstract Background Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targets. Methods First, we comprehensively investigated the causal associat...

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Hauptverfasser:	Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-09-01
Schriftenreihe:	BMC Medicine
Schlagworte:	Plasma proteome Multiple myeloma Drug target Bayesian model Mendelian randomization Enrichment pathway analysis
Online-Zugang:	https://doi.org/10.1186/s12916-023-03086-0
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