Dual targeting of solid tumors using cytokine-induced killer cells modified with a CAR anti-tenascin C and a secretable EGFRxCD3 bispecific antibody

Abstract To generate CARCIK cells with enhanced targeting and penetration of solid tumors, we have designed new CAR molecules against tenascin C (TNC), an extracellular matrix and surface molecule, overexpressed in several tumor types. Two different anti-TNC CAR constructs were generated, sharing th...

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Bibliographic Details

Main Authors:	Silvia Zaninelli, Irene Cattaneo, Rut Valgardsdottir, Roberta Frapolli, Ezia Bello, Marina Meroni, Andrea Gianatti, Silvia Panna, Paola Rizzo, Susanna Tomasoni, Maurizio D’Incalci, Martino Introna, Josée Golay, Alessandro Rambaldi
Format:	Artigo
Language:	Inglês
Published:	Springer 2025-09-01
Series:	Cancer Immunology, Immunotherapy
Subjects:	Chimeric antigen receptor Tenascin C Cytokine induced killer Bispecific T cell engager solid tumor
Online Access:	https://doi.org/10.1007/s00262-025-04149-2
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