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Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

Abstract Background Cellular iron homeostasis is regulated by iron regulatory proteins (IRP1 and IRP2) that sense iron levels (and other metabolic cues) and modulate mRNA translation or stability via interaction with iron regulatory elements (IREs). IRP2 is viewed as the primary regulator in the liv...

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Principais autores: Hima Priyanka Nadimpalli, Georgia Katsioudi, Enes Salih Arpa, Lies Chikhaoui, Alaaddin Bulak Arpat, Angelica Liechti, Gaël Palais, Claudia Tessmer, Ilse Hofmann, Bruno Galy, David Gatfield
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-05-01
coleção:Genome Biology
Assuntos:
Iron metabolism
Liver
IRP
IRE
Translation
Ribosome profiling
Acesso em linha:https://doi.org/10.1186/s13059-024-03270-2
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