The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation

Tumor cells develop various mechanisms to escape immune surveillance. In this context, oncometabolites secreted by tumor cells due to deregulated metabolic pathways, have been in the spotlight of researchers during the last years. 5′-Deoxy-5′-methylthioadenosine (MTA) phosphorylase (MTAP) deficiency...

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Detalhes bibliográficos

Principais autores:	Benedikt Jacobs, Sebastian Schlögl, Carolin Dorothea Strobl, Simon Völkl, Andrej Stoll, Dimitrios Mougiakakos, Karl-Johan Malmberg, Andreas Mackensen, Michael Aigner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-10-01
coleção:	Frontiers in Immunology
Assuntos:	NKG2C CD16 signaling 5′-deoxy-5′-methylthioadenosine NK cells tumor escape mechanism
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.02128/full
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