Expression of <it>Fused in sarcoma</it> mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

<p>Abstract</p> <p>Background</p> <p>Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD). FUS accumulates in neuronal cytoplasmic inclusions (NCIs) in ALS patients w...

Повний опис

Бібліографічні деталі

Автори:	Verbeeck Christophe, Deng Qiudong, DeJesus-Hernandez Mariely, Taylor Georgia, Ceballos-Diaz Carolina, Kocerha Jannet, Golde Todd, Das Pritam, Rademakers Rosa, Dickson Dennis W, Kukar Thomas
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2012-10-01
Серія:	Molecular Neurodegeneration
Предмети:	Amyotrophic lateral sclerosis Frontotemporal lobar degeneration Fused in sarcoma proteinopathies Transgenic mouse models Adeno-associated virus Neuronal cytoplasmic inclusions Ubiquitin p62/SQSTM1 α-internexin PABP-1 Stress granules RNA dysfunction
Онлайн доступ:	http://www.molecularneurodegeneration.com/content/7/1/53
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!