The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4

Anaplastic lymphoma kinase (ALK) fusion events lead to constitutive activation of the ALK kinase domain, thereby functioning as oncogenic drivers. These fusion proteins have been identified in numerous cancers. Crizotinib, a small molecule inhibitor of c-Met and ALK, is a Food and Drug Administratio...

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Bibliografische Detailangaben

Hauptverfasser:	Yoo Jin Kim, A-Ri Cho, Hee Jung Sul, Bohyun Kim, A-Young Kim, Hyeong Su Kim, Jong Bok Seo, Youngho Koh, Dae Young Zang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	The Company of Biologists 2019-07-01
Schriftenreihe:	Biology Open
Schlagworte:	Crizotinib Drosophila Cancer Fusion gene (TPM4-ALK)
Online-Zugang:	http://bio.biologists.org/content/8/7/bio044362
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