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A Single Nucleotide C3 Polymorphism Associates With Clinical Outcome After Lung Transplantation

Background: Development of chronic rejection is still a severe problem and causes high mortality rates after lung transplantation (LTx). Complement activation is important in the development of acute rejection (AR) and bronchiolitis obliterans syndrome, with C3 as a key complement factor.Methods: We...

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Guardat en:
Autors principals: Tineke Kardol-Hoefnagel, Kevin Budding, Eduard A. van de Graaf, Jessica van Setten, Oliver A. van Rossum, Erik-Jan D. Oudijk, Henderikus G. Otten
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019-09-01
Col·lecció:Frontiers in Immunology
Matèries:
lung transplantation
complement component 3
acute rejection
bronchiolitis obliterans syndrome
BALF
transplantation genetics
Accés en línia:https://www.frontiersin.org/article/10.3389/fimmu.2019.02245/full
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