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Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol

Patients with chronic lung disease, obesity, and other co-morbid conditions are at increased risk of severe illness and death when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypercapnia, the elevation of CO2 in blood and tissue, commonly occurs in patients with sever...

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Principais autores: Fei Chen, Aiko Matsuda, G. R. Scott Budinger, Peter H. S. Sporn, S. Marina Casalino-Matsuda
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251120/full
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