Functional Characterization of the A414G Loss-of-Function Mutation in <i>HCN4</i> Associated with Sinus Bradycardia
Patients carrying the heterozygous A414G mutation in the <i>HCN4</i> gene, which encodes the HCN4 protein, demonstrate moderate to severe bradycardia of the heart. Tetramers of HCN4 subunits compose the ion channels in the sinus node that carry the hyperpolarization-activated ‘funny’ current (I<sub>...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI AG
2023-08-01
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| Serier: | Cardiogenetics |
| Fag: | |
| Online adgang: | https://www.mdpi.com/2035-8148/13/3/12 |
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