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Integrated multi-omics characterization of SPTBN2 overexpression reveals its pro-tumorigenic role and immune microenvironment remodeling in colorectal cancer

BackgroundColorectal cancer (CRC) is highly heterogeneous, which limits the consistency of benefit from immune checkpoint blockade. SPTBN2 has recently been implicated as a candidate biomarker in CRC, but its cross-omics features and potential links to the tumor immune microenvironment remain insuff...

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主要な著者: Chunlin Chen, Guohua Hao, Zhihua Cheng, Meiling Wang, Fei Sun, Yi Huang
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2026-05-01
シリーズ:Frontiers in Cell and Developmental Biology
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オンライン・アクセス:https://www.frontiersin.org/articles/10.3389/fcell.2026.1795514/full
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