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Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

Objectives: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). Methods: Female mice expressing the Ca2+ indicator GCaMP3 specifically in alpha-cells were fed...

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Principais autores: Joely A. Kellard, Nils J.G. Rorsman, Thomas G. Hill, Sarah L. Armour, Martijn van de Bunt, Patrik Rorsman, Jakob G. Knudsen, Linford J.B. Briant
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-10-01
Serier:Molecular Metabolism
Fag:
Diabetes
High fat diet
Islet of Langerhans
Alpha cell
Insulin tolerance
Hyperglucagonemia
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877820300958
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