Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response <i>in vitro</i>

The nucleotide binding oligomerization domain containing 2 (NOD2) protein and its ligand N-acetyl muramyl dipeptide (MDP) are crucially involved in Crohn’s disease (CD). However, the mechanism by which NOD2 signaling is regulated in CD patients remains unclear. Ubiquitin specific protease (USP14) i...

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Hlavní autoři:	Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	PAGEPress Publications 2024-09-01
Edice:	European Journal of Histochemistry
Témata:	Inflammatory bowel disease Crohn’s disease USP14 MAPK NF-κB
On-line přístup:	https://www.ejh.it/ejh/article/view/4101
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