Immunogenic shift of arginine metabolism triggers systemic metabolic and immunological reprogramming to suppress HER2 + breast cancer

Abstract Background Arginine metabolism in tumors is often shunted into the pathway producing pro-tumor and immune suppressive polyamines (PAs), while downmodulating the alternative nitric oxide (NO) synthesis pathway. Aiming to correct arginine metabolism in tumors, arginine deprivation therapy and...

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Detalhes bibliográficos

Principais autores:	Vandana Sharma, Veani Fernando, Xunzhen Zheng, Eun-Seok Choi, Osama Sweef, Venetia Thomas, Justin Szpendyk, Saori Furuta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-03-01
Colecção:	Cancer & Metabolism
Assuntos:	Breast cancer Arginine Metabolism HER2 Cancer prevention Nitric oxide
Acesso em linha:	https://doi.org/10.1186/s40170-025-00384-4
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