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Effect of biliary drainage and biliary tract infection in unresectable pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid: a multicenter, prospective cohort study (NAPOLEON-2)

Abstract Background The effectiveness and safety of nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) in patients with unresectable or recurrent pancreatic cancer with or without prior biliary drainage (BD) or on-treatment biliary tract infection (BTI) in the real world are unclear....

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Main Authors: Wataru Yoshioka, Tsuyoshi Shirakawa, Mototsugu Shimokawa, Taiga Otsuka, Futa Koga, Noriko Oza, Hirokazu Takahashi, Masayuki Kitsuka, Junichi Nakazawa, Hozumi Shimokawa, Yudai Shinohara, Hisanobu Oda, Shigeyuki Takeshita, Shiho Arima, Shuji Arita, Yasunori Kawaguchi, Kazuo Nishikawa, Satoshi Otsu, Hiroki Taguchi, Kenichi Jikuya, Tatsunori Sakai, Yujiro Ueda, Takahiro Sakae, Norimasa Araki, Hironori Sawase, Yasushi Ide, Machiko Kawahira, Kenta Nio, Toshihiko Mizuta, Kenji Mitsugi
Format: Artigo
Language:Inglês
Published: BMC 2026-05-01
Series:BMC Cancer
Subjects:
Biliary drainage
Biliary tract infection
Landmark analysis
Pancreatic cancer
Nanoliposomal irinotecan
Online Access:https://doi.org/10.1186/s12885-026-16237-2
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