The C-terminal region of <it>Bfl-1 </it>sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing <it>NF-κB </it>activity and down-regulating Bfl-1

<p>Abstract</p> <p>Gemcitabine is used to treat several cancers including lung cancer. However, tumor cells often escape gemcitabine-induced cell death via various mechanisms, which include modulating bcl-2 family members and NF-κB activation. We previously reported that the C-terminal region of Bfl...

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Autors principals:	Kim Min-Kyoung, Jeon Yoon-Kyung, Woo Jong-Kyu, Choi Yun, Choi Dae-Han, Kim Yeul-Hong, Kim Chul-Woo
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2011-08-01
Col·lecció:	Molecular Cancer
Matèries:	gemcitabine NF-κB Bfl-1 gene therapy non-small cell lung cancer
Accés en línia:	http://www.molecular-cancer.com/content/10/1/98
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