Activated partial thromboplastin time prolongation without hemorrhagic dienhesis: a study of a chinese family coexisting with hereditary KNG1 p.Arg240 mutation and --SEA/αα genotype thalassemia

Abstract High molecular weight kininogen (HK) deficiency is a rare autosomal recessive disorder caused by mutations in the KNG1 gene. This study reports a 66-year-old male Chinese patient who presented with significantly prolonged activated partial thromboplastin time (aPTT) and microcytic hypochrom...

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Detalhes bibliográficos

Principais autores:	Zhiyao Bai, Jiayi Hu, Yanling Jin, Xiaodong Li, Jiqin Sun, Fan Zhang, Di Wu, Fengxiao Zhao, Ping Ji
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2026-02-01
coleção:	Annals of Hematology
Assuntos:	Activated partial thromboplastin time (aPTT) High molecular weight kininogen (HMWK) Kininogen-1 (KNG1)
Acesso em linha:	https://doi.org/10.1007/s00277-026-06853-0
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