Repetitive mild traumatic brain injury with the closed-head impact model of engineered rotational acceleration (CHIMERA) promotes tau pathology in tau transgenic mice and its propagation in brains injected with tau fibrils

Abstract Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease characterized by the presence of abnormally phosphorylated tau aggregates. Tau is a microtubule-associated protein expressed mainly in axons of neurons with a role in the regulation of microtubule dynamics and...

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Principais autores:	Taeko Kimura, Masami Masuda-Suzukake, Masashi Hashimoto, Kazunari Sekiyama, Fuyuki Kametani, Taisuke Tomita, Hirofumi Aoyagi, Shin-ichi Hisanaga, Masato Hasegawa
格式:	Artigo
語言:	Inglês
出版:	BMC 2026-01-01
叢編:	Acta Neuropathologica Communications
主題:	Tauopathy Repetitive mild traumatic brain injury CHIMERA Tau propagation Chronic traumatic encephalopathy Neurodegeneration
在線閱讀:	https://doi.org/10.1186/s40478-025-02177-8
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