Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity

Abstract IL-2 is the master-regulator cytokine for T cell dependent responses and is crucial for proliferation and survival of T cells. However, IL-2-based treatments remained marginal, in part due to short half-life. Thus, we aimed to extend IL-2 half-life by flanking the IL-2 core with sequences d...

Descrición completa

Detalles Bibliográficos

Principais autores:	Aner Ottolenghi, Priyanka Bolel, Rhitajit Sarkar, Yariv Greenshpan, Muhammed Iraqi, Susmita Ghosh, Baisali Bhattacharya, Zoe V. Taylor, Kiran Kundu, Olga Radinsky, Roi Gazit, David Stepensky, Ron N. Apte, Elena Voronov, Angel Porgador
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2021-04-01
Series:	Scientific Reports
Acceso en liña:	https://doi.org/10.1038/s41598-021-87102-4
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!