Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

Abstract Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in the co‐regulation of genes in two neurodegenerative diseases, late‐onset Alzheimer's disease (AD) and Huntington's disease (HD). We i...

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Autori principali:	Manikandan Narayanan, Jimmy L Huynh, Kai Wang, Xia Yang, Seungyeul Yoo, Joshua McElwee, Bin Zhang, Chunsheng Zhang, John R Lamb, Tao Xie, Christine Suver, Cliona Molony, Stacey Melquist, Andrew D Johnson, Guoping Fan, David J Stone, Eric E Schadt, Patrizia Casaccia, Valur Emilsson, Jun Zhu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2014-07-01
Serie:	Molecular Systems Biology
Soggetti:	differential co‐expression dysregulatory gene networks epigenetic regulation of neural differentiation network alignment neurodegenerative diseases
Accesso online:	https://doi.org/10.15252/msb.20145304
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