Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro

Oligonucleotides and nucleic acid analogues that alter gene expression are now showing therapeutic promise in human disease. Whilst the modification of synthetic nucleic acids to protect against nuclease degradation and to influence drug function is common practice, such modifications may also confe...

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Bibliografiske detaljer

Principais autores:	Loren L. Flynn, Ruohan Li, Ianthe L. Pitout, May T. Aung-Htut, Leon M. Larcher, Jack A. L. Cooper, Kane L. Greer, Alysia Hubbard, Lisa Griffiths, Charles S. Bond, Steve D. Wilton, Archa H. Fox, Sue Fletcher
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2022-04-01
Serier:	Frontiers in Genetics
Fag:	antisense oligonucleotides RNA analogue RNA processing paraspeckle nuclear organelles phosphorothioate morpholino oligomer
Online adgang:	https://www.frontiersin.org/articles/10.3389/fgene.2022.791416/full
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