Upregulation of miR-151a-5p in high DFI sperm induces DNA damage and mitochondrial dysfunction by targeting INPP4B and VAMP1

Abstract Objective To explore the potential the role of miR-151a-5p in sperm dysfunction and its association with DNA fragmentation, mitochondrial dysfunction, and male infertility. Methods Sperm samples with high DNA fragmentation were collected, and miR-151a-5p expression was measured using quanti...

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Bibliografski detalji

Glavni autori:	Xiaoting Lin, Jiaming Guo, Xibo Wang, Xi Xiao, Jie Sun, Wen Ding, Yun Peng, Hongli Yan
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-11-01
Serija:	Reproductive Biology and Endocrinology
Teme:	Sperm DNA fragmentation index Small non-coding RNA MicroRNA MiR-151a-5p Sperm function
Online pristup:	https://doi.org/10.1186/s12958-025-01474-0
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