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Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway

Triple-negative breast cancer (TNBC) is an aggressive disease with worst prognosis than other subtypes of breast cancer. Owing to the lack of hormone receptors and HER2 expression on TNBC cells, patients do not have targeted therapy options available with other breast cancer subtypes. Extensive effo...

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Principais autores: Xiaohong Chen, Shuang Li, Dan Li, Muxia Li, Ziren Su, Xiaoping Lai, Changlin Zhou, Shaodan Chen, Shunxian Li, Xiaobing Yang, Jiyan Su, Yunjian Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-04-01
Serier:Frontiers in Pharmacology
Fag:
Brucea javanica
triple-negative breast cancer (TNBC)
autophagy
PI3K/Akt/mTOR
toxicity
Online adgang:https://www.frontiersin.org/article/10.3389/fphar.2020.00606/full
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