Flavonoid-modulated JAK-STAT signaling mitigates malignant transformation and drug resistance in breast tumors: A clinically relevant 3PM-guided innovation

Background: Breast cancer (BC) treatment efficacy is often compromised by tumor cell plasticity and multidrug resistance of multi-factorial origin. Among emerging therapeutic agents, flavonoids − a structurally diverse group of naturally occurring polyphenols − have demonstrated a significant potent...

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Bibliografische Detailangaben

Hauptverfasser:	Peter Kubatka, Mykhailo Huniadi, Andrea Kapinova, Natalia Nosalova, Elizabeth Varghese, Dana Blahutova, Slavomir Hornak, Alexandra Trbolova, Kamil Biringer, Katarina Adamicova, Dasa Cizkova, Dietrich Büsselberg, Olga Golubnitschaja
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-07-01
Schriftenreihe:	Journal of Advanced Research
Schlagworte:	Breast carcinoma Predictive preventive personalized medicine (PPPM / 3PM) Cancer chemo-resistance Cell plasticity Anti-cancer therapy Re-sensitization
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S209012322500863X
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