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Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial

Abstract Background Studies in murine models suggested that platelet desialylation was an important mechanism of thrombocytopenia during sepsis. Methods First, we performed a prospective, multicenter, observational study that enrolled septic patients with or without thrombocytopenia to determine the...

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Autori principali: Mei-feng Li, Xiao-li Li, Kai-liang Fan, Ying-yi Yu, Jing Gong, Shu-ying Geng, Ya-feng Liang, Ling Huang, Ji-hua Qiu, Xing-han Tian, Wen-ting Wang, Xiao-lu Zhang, Qing-xia Yu, Yuan-feng Zhang, Peng Lin, Li-na Wang, Xin Li, Ming Hou, Lu-yi Liu, Jun Peng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-05-01
Serie:Journal of Hematology & Oncology
Soggetti:
Sepsis
Thrombocytopenia
Oseltamivir
Desialylation
Platelet
Accesso online:http://link.springer.com/article/10.1186/s13045-017-0476-1
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