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Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA

Despite research efforts full potential of siRNA-based therapeutics has not yet been fully realized due to a need for suitable, effective delivery formulations. Here, we examine a potential of a new class of water-soluble chitosans as siRNA platform for pulmonary delivery. The system is based on pip...

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Principais autores: Victoria Capel, Driton Vllasaliu, Peter Watts, Philip A. Clarke, Dominic Luxton, Anna M. Grabowska, Giuseppe Mantovani, Snjezana Stolnik
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2018-01-01
coleção:Drug Delivery
Assuntos:
chitosan
sirna delivery
sirna complex
lung inhalation
ivis imaging
Acesso em linha:http://dx.doi.org/10.1080/10717544.2018.1440668
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