Integrating rna structure and protein interactions to uncover the mechanisms of viral and cellular ires function

Abstract Background RNAs fold into complex structures that critically influence gene expression. A prominent class of regulatory elements resides in the 5′ untranslated region (5′ UTR), where internal ribosome entry sites (IRESs) promote cap-independent translation by directly engaging the ribosome....

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Hlavní autoři:	Riccardo Delli Ponti, Andrea Vandelli, Laura Broglia, Gian Gaetano Tartaglia
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	Biology Direct
Témata:	Internal ribosome entry sites (IRESs) RNA viruses RNA secondary structure Protein-RNA interactions IRES trans-acting factor (ITAF) Translation regulation
On-line přístup:	https://doi.org/10.1186/s13062-025-00706-y
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