SREBP1 regulates Lgals3 activation in response to cholesterol loading

Aberrant smooth muscle cell (SMC) plasticity is etiological to vascular diseases. Cholesterol induces SMC phenotypic transition featuring high LGALS3 (galectin-3) expression. This proatherogenic process is poorly understood for its molecular underpinnings, in particular, the mechanistic role of ster...

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Principais autores:	Jing Li, Hongtao Shen, Gary K. Owens, Lian-Wang Guo
格式:	Artigo
语言:	Inglês
出版:	Elsevier 2022-06-01
丛编:	Molecular Therapy: Nucleic Acids
主题:	vascular smooth muscle cell cholesterol loading phenotypic transition SREBP1 LGALS3 feedforward circuit
在线阅读:	http://www.sciencedirect.com/science/article/pii/S216225312200141X
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