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Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit

Abstract Background In critically ill children, omitting early use of parenteral nutrition (late-PN versus early-PN) reduced infections, accelerated weaning from mechanical ventilation, and shortened PICU stay. We hypothesized that fasting-induced ketogenesis mediates these benefits. Methods In a se...

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Autori principali: Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche, Greet Van den Berghe
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-08-01
Serie:Critical Care
Soggetti:
Parenteral nutrition
Intensive care
Ketogenesis
Ketone body
Recovery
Accesso online:http://link.springer.com/article/10.1186/s13054-020-03256-z
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