Intratumoral delivery of mRNA encoding the endogenous TLR2/6 agonist UNE-C1 induces immunogenic cell death and enhances antitumor activity

IntroductionRecent investigations have highlighted the intratumoral administration of Toll-like receptor (TLR) ligands as a promising approach to initiate localized immune responses and enhance antitumor immunity. However, the clinical application of these ligands is limited by their rapid dissemina...

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Κύριοι συγγραφείς:	Uijoo Kim, Sunkyo Hwang, Seongmin Cho, Hyeong Yun Kim, Hamin Ban, Joohee Park, Jeongwon Mun, Nayoung Kim, Ji Hun Suh, Jihye Choi, Yungyeong Shin, Sang Bum Kim, Ina Yoon, Hyuk-Sang Kwon, Sunghoon Kim
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2024-11-01
Σειρά:	Frontiers in Immunology
Θέματα:	cancer immunotherapy toll-like receptor intratumoral treatment mRNA therapeutics tumor microenvironment immunogenic cell death
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454504/full
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