Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omicsResearch in context

Summary: Background: Which cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is co...

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Auteurs principaux:	Zihao Mi, Zhenzhen Wang, Yi Wang, Xiaotong Xue, Xiaojie Liao, Chuan Wang, Lele Sun, Yingjie Lin, Jianwen Wang, Dianhao Guo, Tingting Liu, Jianjun Liu, Robert L. Modlin, Hong Liu, Furen Zhang
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-10-01
Collection:	EBioMedicine
Sujets:	Infectious granulomas Leprosy Bacterial burden Single-cell multimodal omics Mycobacteria Immunotherapy
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2352396424003785
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