Discovery of N8: a novel IKKε inhibitor with potent anticancer activity via cytotoxicity, migration suppression, and autophagy modulation

The serine/threonine kinase IKKε is overexpressed or activated in various cancers, making it a promising therapeutic target. Through a large-scale virtual screening of over 12 million compounds, we identified N8 as a novel IKKε inhibitor, selected for its favourable docking score and drug-likeness p...

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Detalhes bibliográficos

Principais autores:	Wei Ye, Siying Zheng, Hongmei Xie, Xinrui Zhou, Jiapeng Xu, Qiting Luo, Yuanyuan Huang, Jieyu Li, Jiayi Diao, Xinyi Luo, Qinchang Zhu, Ge Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
Colecção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	Targeted cancer therapy IKKε inhibitor virtual screening autophagy
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2607808
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