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DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ASSAY OF SUBSTRATES-MARKERS OF MAIN CYTOCHROME P450 ISOFORMS AND THEIR METABOLITES USING HPLC-MS/MS

Simultaneous quantification method of assaying main CYP isoforms substrates-markers and their metabolites in urine using HPLC-MS/MS was developed to determine activity of following isoforms: caffeine/paraxanthine for CYP1A2, losartane/E-3174 for CYP2C9, cortisole/6-β-hydroxycortisole for CYP3A4 and...

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Guardat en:
Autors principals: E. A. Egorenkov, V. V. Smirnov
Format: Artigo
Idioma:Russo
Publicat: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Col·lecció:Разработка и регистрация лекарственных средств
Matèries:
cytochrome p450
cyp1a2
cyp2c9
cyp3a4
cyp2d6
«cocktail» method
phenotyping
caffeine
losartane
cortisole
pinoline
Accés en línia:https://www.pharmjournal.ru/jour/article/view/175
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