Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia

ABSTRACT Streptococcus pneumoniae (Sp), a leading cause of community-acquired pneumonia, can spread from the lung into the bloodstream to cause septicemia and meningitis, with a concomitant threefold increase in mortality. Limitations in vaccine efficacy and a rise in antimicrobial resistance have s...

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Bibliografische gegevens

Hoofdauteurs:	Shuying Xu, Shumin Tan, Patricia Romanos, Jennifer L. Reedy, Yihan Zhang, Michael K. Mansour, Jatin M. Vyas, Joan Mecsas, Hongmei Mou, John M. Leong
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology 2024-09-01
Reeks:	mBio
Onderwerpen:	Streptococcus pneumoniae airway mucosal barrier neutrophil transmigration neutrophil elastase 12-lipoxygenase
Online toegang:	https://journals.asm.org/doi/10.1128/mbio.01856-24
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