Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention

Abstract Background Peripheral neuropathy (PN) constitutes a dose-limiting side effect of oxaliplatin chemotherapy that often compromises the efficacy of antineoplastic treatments. Sensory neurons damage in dorsal root ganglia (DRG) are the cellular substrate of PN complex molecular origin. Dehydrop...

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Главные авторы:	Karen Álvarez-Tosco, Rebeca González-Fernández, María Ángeles González-Nicolás, Rita Martín-Ramírez, Manuel Morales, Ricardo Gutiérrez, Lucio Díaz-Flores, María Rosa Arnau, Félix Machín, Julio Ávila, Alberto Lázaro, Pablo Martín-Vasallo
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-09-01
Серии:	BMC Neuroscience
Предметы:	Dorsal root ganglion (DRG) Oxaliplatin Neurotoxicity DRG-inflammation Dehydropeptidase-1 (DPEP1) Allodynia
Online-ссылка:	https://doi.org/10.1186/s12868-024-00891-y
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