Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer

Abstract Ferroptosis, a novel form of regulated cell death induced by the excessive accumulation of lipid peroxidation products, plays a pivotal role in the suppression of tumorigenesis. Two prominent mitochondrial ferroptosis defense systems are glutathione peroxidase 4 (GPX4) and dihydroorotate de...

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Autors principals:	Ru Deng, Lingyi Fu, Haoyu liang, Xixiong Ai, Fangyi Liu, Nai Li, Liyan Wu, Shuo Li, Xia Yang, Yansong Lin, Yuhua Huang, Jingping Yun
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2025-04-01
Col·lecció:	Cell Death and Disease
Accés en línia:	https://doi.org/10.1038/s41419-025-07510-6
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