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Enhanced Anti-Tumor Effect of Folate-Targeted FA-AMA-hyd-DOX Conjugate in a Xenograft Model of Human Breast Cancer

Folate-aminocaproic acid-doxorubicin (FA-AMA-hyd-DOX) was firstly synthesized by our group. It was indicated that FA-AMA-hyd-DOX was pH-responsive, and had strong cytotoxicity on a folate receptor overexpressing cell line (KB cells) in vitro. The aim of our study was to further explore the potential...

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Principais autores: Tian-tian Liao, Jiang-fan Han, Fei-yue Zhang, Ren Na, Wei-liang Ye
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-11-01
coleção:Molecules
Assuntos:
breast cancer
doxorubicin
prodrug delivery
cancer targeted therapy
biosafety
Acesso em linha:https://www.mdpi.com/1420-3049/26/23/7110
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