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Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis

Triple-negative breast cancer (TNBC) harbors a high percentage of breast cancer stem-like cells (BCSCs) that significantly contribute to poor prognosis, metastasis, and relapse of the disease. Thus, targeting BCSCs could be a promising approach to combat TNBC. In this context, we investigated nimbol...

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Principais autores: Priyanka Mohapatra, Swati Madhulika, Somalisa Behera, Priya Singh, Pratikshya Sa, Punit Prasad, Rajeeb Kumar Swain, Sanjeeb Kumar Sahoo
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2023-12-01
סדרה:Molecular Therapy: Nucleic Acids
נושאים:
MT: Delivery Strategies
triple-negative breast cancer
cancer stem cells
nanomedicine
nimbolide
epigenetics
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2162253123002445
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