Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Introduction: Aging studies in humans and mice have played a key role in understanding the intestinal microbiome and an increased abundance of “inflammaging” Gram-negative (Gn) bacteria. The mechanisms underlying this inflammatory profile in the aging microbiome are unknown. We tested the hypothesis...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Christopher B. Forsyth, Maliha Shaikh, Phillip A. Engen, Fabian Preuss, Ankur Naqib, Breanna A. Palmen, Stefan J. Green, Lijuan Zhang, Zlata R. Bogin, Kristi Lawrence, Deepak Sharma, Garth R. Swanson, Faraz Bishehsari, Robin M. Voigt, Ali Keshavarzian
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-03-01
Schriftenreihe:	Frontiers in Aging
Schlagworte:	aging tight junction microbiota gene expression anti-microbial peptides dysbiosis
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fragi.2024.1352299/full
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