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Synthesis and Receptor Binding Studies of α5 GABA<sub>A</sub>R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders

GABA mediates inhibitory actions through various GABA<sub>A</sub> receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizophrenia. Selective targeting of α2/3 GAB...

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Main Authors: Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M. Cook
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
γ-Aminobutyric acid (GABA)
positive allosteric modulator
cognitive disorders
imidazodiazepine
PDSP
off-target profile
Online Access:https://www.mdpi.com/1420-3049/28/12/4771
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