Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective

IntroductionMultiple myeloma (MM) develops within a profoundly immunosuppressive bone marrow (BM) microenvironment. CD38, a multifunctional ectoenzyme highly expressed on malignant plasma cells, contributes to this niche by degrading nicotinamide adenine dinucleotide (NAD+) into ADPR, which fuels ad...

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Библиографические подробности

Главные авторы:	Alberto L. Horenstein, Kristine A. Frerichs, Angelo C. Faini, Niels W. C. J. van de Donk, Fabio Malavasi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-04-01
Серии:	Frontiers in Immunology
Предметы:	adenosine CD38 daratumumab immunosuppression immunotherapy inosine
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1769281/full
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