Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5

Acute myeloid leukemia (AML) therapy involves compounds that are cytotoxic to both normal and cancer cells, and relapsed AML is resistant to subsequent chemotherapy. Thus, agents are needed that selectively kill AML cells with minimal toxicity. Here, we report that AML is dependent on DDX5 and that...

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Bibliografske podrobnosti

Principais autores:	Anthony Mazurek, Youngkyu Park, Cornelius Miething, John E. Wilkinson, Jesse Gillis, Scott W. Lowe, Christopher R. Vakoc, Bruce Stillman
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2014-06-01
Serija:	Cell Reports
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124714003945
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