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Loss of Growth Differentiation Factor 11 Shortens Telomere Length by Downregulating Telomerase Activity

Maintenance of telomere length is essential to delay replicative cellular senescence. It is controversial on whether growth differentiation factor 11 (GDF11) can reverse cellular senescence, and this work aims to establish the causality between GDF11 and the telomere maintenance unequivocally. Using...

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Principais autores: Di-Xian Wang, Xu-Dong Zhu, Xiao-Ru Ma, Li-Bin Wang, Zhao-Jun Dong, Rong-Rong Lin, Yi-Na Cao, Jing-Wei Zhao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-09-01
Serier:Frontiers in Physiology
Fag:
growth differentiation factor 11
telomere length
TERT
TERC
telomerase activity
Smad2
Online adgang:https://www.frontiersin.org/articles/10.3389/fphys.2021.726345/full
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