Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and result in massive bone loss. During RANKL‐induced osteoclastogenesis, pyroptosis of macrophages/preosteoclasts acts as a pivotal mechanism for IL‐1β release, thereby promoting osteoclast maturatio...

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Detalhes bibliográficos

Principais autores:	Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-08-01
coleção:	Advanced Science
Assuntos:	inflammatory related bone loss NEK7 osteoclastogenesis Pinosylvin pyroptosis
Acesso em linha:	https://doi.org/10.1002/advs.202501532
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