Therapeutic misalignment averted by clonal evolutionary evidence: molecular confirmation of hepatic metastasis in SMARCA4-deficient non-small cell lung cancer initially misdiagnosed as resectable cholangiocarcinoma

ObjectivesSMARCA4-deficient non-small cell lung cancer (SMARCA4-dNSCLC) exhibits significant histomorphological diversity and intertumoral heterogeneity. Immunophenotypically, it often lacks lineage-specific markers, making diagnosis challenging, especially in cases of hepatic metastasis. Currently,...

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Principais autores:	Ruirui Fan, Yanyan Zhan, Junrong Yan, Jie Gao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Oncology
Assuntos:	clonal evolution analysis hepatic metastasis molecular profiling pathological diagnosis SMARCA4-deficient non-small cell lung cancer
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1743908/full
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