A Phase IB Trial of Selinexor in Combination With Immune Checkpoint Blockade in Patients With Advanced Renal Cell Carcinoma
ABSTRACT Background Selinexor (SEL) is a nuclear exportin 1 inhibitor that blocks the transport of nuclear proteins, including tumor suppressors, to the cytoplasm. Preclinical data suggest that the combination of SEL with checkpoint blockade may result in improved response to immunotherapy. Methods...
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| Główni autorzy: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Wiley
2025-02-01
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| Seria: | Cancer Medicine |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1002/cam4.70280 |
| Etykiety: |
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