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RNase P Ribozyme Effectively Inhibits Human CC-Chemokine Receptor 5 Expression and Human Immunodeficiency Virus 1 Infection

Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro. Here, engineered ribozymes were constructed from an RNase P ribozyme variant t...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Bin Yan, Yujun Liu, Yuan-Chuan Chen, Isadora Zhang, Fenyong Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-04-01
Schriftenreihe:Zoonotic Diseases
Schlagworte:
RNase P
HIV
gene targeting
gene therapy
antisense
Online-Zugang:https://www.mdpi.com/2813-0227/3/2/9
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