Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity.

Several proteins that play key roles in cholesterol synthesis, regulation, trafficking and signaling are united by sharing the phylogenetically conserved 'sterol-sensing domain' (SSD). The intracellular parasite Toxoplasma possesses at least one gene coding for a protein containing the canonical SSD...

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Detalhes bibliográficos

Principais autores:	Bao Lige, Julia D Romano, Veera Venkata Ratnam Bandaru, Karen Ehrenman, Jelena Levitskaya, Vera Sampels, Norman J Haughey, Isabelle Coppens
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2011-12-01
coleção:	PLoS Pathogens
Acesso em linha:	http://europepmc.org/articles/PMC3234224?pdf=render
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