Calculating maternal polygenic risk scores from prenatal screening by cell-free DNA data

Polygenic Risk Scores (PRS) have enabled quantification of genetic risk for many common and complex traits. Here we developed a novel method to estimate maternal PRS using low-coverage whole genome sequencing data from prenatal screening by cell-free DNA data intended to screen for fetal chromosomal...

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Auteurs principaux:	Victoria Corey, Mauro Chavez, Layla Qasim, Tevfik U. Dincer, Angela Henry, Salome Bagayan, Sasha Treadup, Mike Mehan, Eileen de Feo, Sung Kim
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2025-02-01
Collection:	Frontiers in Genetics
Sujets:	polygenic risk score prenatal screening cell-free DNA whole genome sequencing imputation
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1495604/full
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